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Saturday, December 6, 2008

D-Cycloserine Facilitates Extinction of Conditioned Alcohol-Seeking Behaviour in Rats
Alcohol and Alcoholism 2008 43(6):626-629

The aim of the present study was to examine the influence of partial NMDA receptor agonist D-cycloserine (DCS) on the extinction of conditioned alcohol-seeking behaviour.

We demonstrate that treatment of rats with 5 mg/kg of DCS was capable in facilitating extinction of conditioned alcohol-seeking behaviour, which subsequently reduced the resumption of extinguished operant responding.

Our study suggests a good rationale for the development of new add-on medications for exposure-based psychotherapy so as to extinguish drug-conditioned appetitive memories in alcohol-dependent patients.

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