Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

___________________________________________

Monday, September 19, 2011

Noninvasive imaging of ethanol-induced developmental defects in zebrafish embryos using optical coherence tomography



In this article, we report the use of optical coherence tomography for noninvasive cross-sectional real-time imaging of ethanol-induced developmental defects in zebrafish embryos larvae.

For ethanol concentration of over 300 mM, developmental defects of eye (shrinkage and retinal abnormalities), malformation of the notochord and ataxia arising due to the toxic effects of ethanol were observed in OCT images from 3 days post fertilization onwards.

The results suggest that OCT could be a valuable tool for noninvasive assessment of birth defects in small animal systems.




Read Full Abstract

Request Reprint E-Mail: kdivakar@rrcat.gov.in